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According to both the American Cancer Society and National Cancer Institute, other risk factors for anal cancer include being over 50 years old, having many sexual partners, having receptive anal intercourse, having a weakened immune system, frequent anal redness and soreness, and being a smoker. Some tumors that develop in the anus are noncancerous. Others start off as benign but develop into cancer over time. What Are the Symptoms of Anal Cancer. In some cases, there are no symptoms associated with anal cancer, but in about half of patients bleeding occurs and is often the first sign of the disease, according to the American Cancer Society.